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She snapped at her mother, locked herself in her room, and talked about wanting to die.
She had friends at school who cut themselves with razors, and she was intrigued by what seemed to be an act of defiance. “The pain felt so real and raw and mine,” she said.
While ketamine has a bad — or great, depending on who you ask — reputation as a street drug, it turns out the anesthetic can do more than slide you into a dissociative state in a crowded nightclub: It can also help your mental health. (The active ingredient in the spray is esketamine, which is the chemical cousin of ketamine.) “There has been a long-standing need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition,” Dr.
Food and Drug Administration announced that it had approved Spravato, a ketamine-like nasal spray for severe depression that experts are heralding as the first novel antidepressant to hit the market since Prozac did 35 years ago.
She hoped that she might discover a more authentic version of herself at Harvard, where she arrived as a freshman in 2001. Sometimes she fashioned herself as a “fun, down-to-earth girl” who drank until early morning with boys who considered her chill.
“That was a recurring theme: whether the surface of people can ever harmonize with what’s inside their minds.”During her winter break, she spent a week in Manhattan preparing for two débutante balls, at the Waldorf-Astoria and at the Plaza Hotel.
She went to a bridal store and chose a floor-length strapless white gown and white satin gloves that reached above her elbows.
All prior antidepressant treatments, such as selective serotonin reuptake inhibitors (SSRIs), temporarily block the body’s reabsorption of serotonin.
Ketamine, on the other hand, targets a completely different set of neurotransmitters and receptors: the glutamate system.